Psychosine-d5(Synonyms: Galactosylsphingosine-d5)

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Psychosine-d5 (Synonyms: Galactosylsphingosine-d5)

Psychosine-d5 是 Psychosine 的氘代物。Psychosine 是半乳糖脑苷脂酶 (GALC) 酶的底物，是 Krabbe 病的潜在生物标志物。Psychosine 是一种高度细胞毒性的脂质，能够在多种细胞类型中诱导细胞死亡，且有部分是通过细胞凋亡 (apoptosis) 导致的细胞死亡。Psychosine 还是一种 PKC 抑制剂。

Psychosine-d5(Synonyms: Galactosylsphingosine-d5)

Psychosine-d5 Chemical Structure

CAS No. : 2260670-12-8

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生物活性

Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.66

Formula

C24H42D5NO7
CAS 号

2260670-12-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121(3):271-278.

    [2]. Jacqueline A Hawkins-Salsbury,et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54(12):3303-11.

    [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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