N-Pyrazinylcarbonylphenylalanine-d8

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N-Pyrazinylcarbonylphenylalanine-d8 

N-Pyrazinylcarbonylphenylalanine-d8 是 Deruxtecan 氘代物。Deruxtecan 是毒性药物和 linker 的偶联物。毒性药物是 DX-8951 (DXd) 衍生物,linker 是马来酰亚胺-GGFG 肽。Deruxtecan 可用于合成 DS-8201 和 U3-1402。

N-Pyrazinylcarbonylphenylalanine-d8

N-Pyrazinylcarbonylphenylalanine-d8 Chemical Structure

CAS No. : 1331912-47-0

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生物活性

N-Pyrazinylcarbonylphenylalanine-d8 is the deuterium labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

279.32

Formula

C14H5D8N3O3

CAS 号

1331912-47-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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