5-Aminolevulinic acid-d2 hydrochloride(Synonyms: 5-ALA-d2 hydrochloride; δ-Aminolevulinic acid-d2 hydrochloride; 5-Amino-4-oxopentanoic acid-d2 hydrochloride)

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5-Aminolevulinic acid-d2 hydrochloride (Synonyms: 5-ALA-d2 hydrochloride; δ-Aminolevulinic acid-d2 hydrochloride; 5-Amino-4-oxopentanoic acid-d2 hydrochloride)

5-Aminolevulinic acid-d2 (hydrochloride) 是 5-Aminolevulinic acid (hydrochloride) 氘代物。5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) 是体内血红素生物合成的中间体,为四吡咯的前体。

5-Aminolevulinic acid-d2 hydrochloride(Synonyms: 5-ALA-d2 hydrochloride; δ-Aminolevulinic acid-d2 hydrochloride; 5-Amino-4-oxopentanoic acid-d2 hydrochloride)

5-Aminolevulinic acid-d2 hydrochloride Chemical Structure

CAS No. : 187237-35-0

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生物活性

5-Aminolevulinic acid-d2 (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

169.60

Formula

C5H8D2ClNO3

CAS 号

187237-35-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.

    [3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.

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