Mirtazapine-d4(Synonyms: Org3770-d4; 6-Azamianserin-d4)

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Mirtazapine-d4 (Synonyms: Org3770-d4; 6-Azamianserin-d4)

Mirtazapine-d4 是 Mirtazapine 氘代物。Mirtazapine (Org3770) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。Mirtazapine 也是一种 5-HT2、5-HT3，组胺 H1 受体 (histamine H1 receptor) 和 α2-肾上腺素受体 (α2-adrenoceptor) 拮抗剂，pKi 值分别为 8.05、8.1、9.3 和 6.95。

Mirtazapine-d4(Synonyms: Org3770-d4; 6-Azamianserin-d4)

Mirtazapine-d4 Chemical Structure

CAS No. : 1215898-55-7

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生物活性

Mirtazapine-d4 is deuterium labeled Mirtazapine. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

269.38

Formula

C17H15D4N3
CAS 号

1215898-55-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. S A Anttila, et al. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. Fall 2001;7(3):249-64.

    [3]. T H de Boer, et al. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology. 1988 Apr;27(4):399-408.

    [4]. Wagdi Almishri, et al. The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice. Front Immunol. 2019 Apr 12;10:803.

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