Travoprost-d4 Acid(Synonyms: 曲伏前列素酸 d4)

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Travoprost-d4 Acid (Synonyms: 曲伏前列素酸 d4)

Travoprost-d4 Acid 是 Travoprost 的氘代物。Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药,是一种高亲和力的,选择性的 FP 前列腺素全受体激动剂。Travoprost 有降眼压功效,有潜力应用于青光眼和眼高压。

Travoprost-d4 Acid(Synonyms: 曲伏前列素酸 d4)

Travoprost-d4 Acid Chemical Structure

CAS No. : 282550-19-0

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生物活性

Travoprost-d4 Acid is the deuterium labeled Travoprost. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester prodrug, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

462.49

Formula

C23H25D4F3O6

CAS 号

282550-19-0

中文名称

曲伏前列素酸 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17(5):421-32.

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