Alimemazine hemitartrate-d6 L-Tartrate(Synonyms: 阿利马嗪半酒石酸 d6（L-酒石酸盐）)

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Alimemazine hemitartrate-d6 L-Tartrate (Synonyms: 阿利马嗪半酒石酸 d6（L-酒石酸盐）)

Alimemazine hemitartrate-d6 (L-Tartrate) 是 Alimemazine hemitartrate 的氘代物。Alimemazine hemitartrate 是通常用作止痒剂的吩噻嗪衍生物,也是血凝素 (HA)-受体的拮抗剂。

Alimemazine hemitartrate-d6 L-Tartrate(Synonyms: 阿利马嗪半酒石酸 d6（L-酒石酸盐）)

Alimemazine hemitartrate-d6 L-Tartrate Chemical Structure

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生物活性

Alimemazine hemitartrate-d6 (L-Tartrate) is the deuterium labeled Alimemazine hemitartrate. Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

454.57

Formula

C22H22D6N2O6S
中文名称

阿利马嗪半酒石酸 d6（L-酒石酸盐）
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

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