Isotretinoin-d5(Synonyms: 异维甲酸 d5)

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Isotretinoin-d5 (Synonyms: 异维甲酸 d5)

Isotretinoin-d5 是 Isotretinoin 的氘代物。Isotretinoin(13-cis-Retinoic acid)可作用于重度粉刺,还可用于脑癌,胰腺癌等化疗。

Isotretinoin-d5(Synonyms: 异维甲酸 d5)

Isotretinoin-d5 Chemical Structure

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生物活性

Isotretinoin-d5 (13-cis-Retinoic acid-d5) is the deuterium labeled Isotretinoin. Isotretinoin(13-cis-Retinoic acid) is a medication used for the research of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

305.47

Formula

C20H23D5O2

中文名称

异维甲酸 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Thielitz, A. and H. Gollnick, [Isotretinoin. How should it be used?]. Hautarzt, 2013. 64(4): p. 263-8.

    [3]. Norris, D.A., et al., Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J Invest Dermatol, 1987. 89(1): p. 38-43.

    [4]. Rademaker, M., J.M. Wishart, and N.M. Birchall, Isotretinoin 5 mg daily for low-grade adult acne vulgaris – a placebo-controlled, randomized double-blind study. J Eur Acad Dermatol Venereol, 2013.

    [5]. Dicken, C.H., Isotretinoin treatment of pityriasis rubra pilaris. J Am Acad Dermatol, 1987. 16(2 Pt 1): p. 297-301.

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