Cyclobenzaprine-d3 hydrochloride(Synonyms: MK130-d3 hydrochloride)

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Cyclobenzaprine-d3 hydrochloride (Synonyms: MK130-d3 hydrochloride)

Cyclobenzaprine-d3 (MK130-d3) hydrochloride 是 Cyclobenzaprine hydrochloride 的氘代物。Cyclobenzaprine hydrochloride (MK130 hydrochloride) 是骨骼肌松弛剂，对中枢神经有活性。

Cyclobenzaprine-d3 hydrochloride(Synonyms: MK130-d3 hydrochloride)

Cyclobenzaprine-d3 hydrochloride Chemical Structure

CAS No. : 1184983-42-3

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生物活性

Cyclobenzaprine-d3 (MK130-d3) hydrochloride is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

314.87

Formula

C20H19D3ClN
CAS 号

1184983-42-3
中文名称

盐酸环苯扎林 d3 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kobayashi, H., Y. Hasegawa, and H. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35.

    [3]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9.

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