3-O-Methyltolcapone D7(Synonyms: Ro 40-7591 D7)

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3-O-Methyltolcapone D7 (Synonyms: Ro 40-7591 D7)

3-O-Methyltolcapone D7 (Ro 40-7591 D7) 是 3-O-Methyltolcapone 的氘代物。3-O-Methyltolcapone 是 Tolcapone 的代谢产物。Tolcapone 是一种口服活性，可逆，选择性和有效的 COMT 抑制剂。Tolcapone 可穿过血脑屏障，可用于研究帕金森氏病。

3-O-Methyltolcapone D7(Synonyms: Ro 40-7591 D7)

3-O-Methyltolcapone D7 Chemical Structure

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生物活性

3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson’s disease[1][2].

IC50 & Target

COMT[1][2]
分子量

294.31

Formula

C15H6D7NO5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jorga K, et al. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase. Br J Clin Pharmacol. 1999 Oct;48(4):513-20.

    [2]. Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson’s disease. Synapse. 2002 Mar 1;43(3):201-7.

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