Equilin-d4(Synonyms: 7-Dehydroestrone-d4)

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Equilin-d4 (Synonyms: 7-Dehydroestrone-d4)

Equilin-d4 (7-Dehydroestrone-d4) 是 Equilin 的氘代物。Equilin (7-Dehydroestrone) 是一大类雌激素物质中的重要成员，与雌二醇有化学关系。Equilin 通过 NMDA 受体依赖机制促进皮层神经元的生长。

Equilin-d4(Synonyms: 7-Dehydroestrone-d4)

Equilin-d4 Chemical Structure

CAS No. : 285979-79-5

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生物活性

Equilin-d4 (7-Dehydroestrone-d4) is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

272.37

Formula

C18H16D4O2
CAS 号

285979-79-5
中文名称

马烯雌酮 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. David K, et al. Some biological properties of equilin. Biochem J. 1935;29(2):371-377.

    [3]. Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147(2):211-220.

    [4]. Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14(1):e0211462. Published 2019 Jan 30.

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