Mandelic acid-2,3,4,5,6-d5(Synonyms: (±)-Mandelic acid-2,3,4,5,6-d5; DL-Mandelic acid-2,3,4,5,6-d5)

发表于由

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Mandelic acid-2,3,4,5,6-d5 (Synonyms: (±)-Mandelic acid-2,3,4,5,6-d5; DL-Mandelic acid-2,3,4,5,6-d5)

Mandelic acid-2,3,4,5,6-d5 ((±)-Mandelic acid-2,3,4,5,6-d5) 是 Mandelic acid 的氘代物。Mandelic acid ((±)-Mandelic acid) 是一种 α-羟基羧酸，广泛用作医药和精细化学品的中间体。Mandelic acid 具有抗菌活性，已用于研究尿路感染和阴道滴虫病。Mandelic acid 具有较高的精子固定活性和较低的阴道刺激性。

Mandelic acid-2,3,4,5,6-d5(Synonyms: (±)-Mandelic acid-2,3,4,5,6-d5; DL-Mandelic acid-2,3,4,5,6-d5)

Mandelic acid-2,3,4,5,6-d5 Chemical Structure

CAS No. : 70838-71-0

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生物活性

Mandelic acid-2,3,4,5,6-d5 ((±)-Mandelic acid-2,3,4,5,6-d5) is the deuterium labeled Mandelic acid. Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

157.18

Formula

C8H3D5O3
CAS 号

70838-71-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Xia M, et al. dl-Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation: A potential non-surfactant spermicide for contraception. Biomed Pharmacother. 2020;126:110104.

    [3]. Tang LP, et al. DL-mandelic acid intercalated Zn-Al layered double hydroxide: A novel antimicrobial layered material. Colloids Surf B Biointerfaces. 2018;165:111-117.

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