Desloratadine-3,3,5,5-d4(Synonyms: 地氯雷他定 d4)

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Desloratadine-3,3,5,5-d4 (Synonyms: 地氯雷他定 d4)

Desloratadine-3,3,5,5-d4 是 Desloratadine 的氘代物。Desloratadine (Sch34117) 是非镇静 H1 抗组胺药 Loratadine 的主要口服代谢物。Desloratadine 是一种选择性 H1 受体拮抗剂,具有抗过敏和抗炎活性。

Desloratadine-3,3,5,5-d4(Synonyms: 地氯雷他定 d4)

Desloratadine-3,3,5,5-d4 Chemical Structure

CAS No. : 2713301-38-1

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生物活性

Desloratadine-3,3,5,5-d4 is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

314.85

Formula

C19H15D4ClN2

CAS 号

2713301-38-1

中文名称

地氯雷他定 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.

    [3]. Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.

    [4]. McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.

    [5]. Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.

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